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Ending Aging

Ending Aging

By Aubrey de Grey & Michael Rae

The Rejuvenation Breakthroughs That Could Reverse Human Aging In Our Lifetime. St Martin’s Press, 2007.

15 min read28 min listen13 chapters

Summary of Ending Aging book by Aubrey de Grey & Michael Rae

A fascinating exploration of the primary causes of aging, explaining scientific research and practical therapies that could address those causes—and sustain human vitality for decades longer than we previously thought possible.

Chapters in Ending Aging book summary

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1

What do you get from this book? An ambitious proposal for how to delay the aging process through bio-engineered solutions

2

The aging process isn’t inevitable: it’s a treatable condition with solutions we can and should pursue

3

Completely preventing or curing aging is too complex to be useful, so it’s better to repair the damage done

4

Mitochondrial cells mutate over time, causing more damage to our bodies—but it’s possible to mitigate this process

5

Our bodies have a waste removal system that is flawed, leaving junk to build up inside and outside our cells

6

Advanced Glycation End-products are the result of complex chemical reactions and they accumulate in our tissues, making them stiffer

7

Targeted cancer therapies could be adapted to help eliminate the “zombie cells” that contribute to aging

8

Stem cells present an incredible opportunity to replace older cells, but political pressure prevents research from advancing in that area

9

De Grey proposes a radical method for replenishing old and damaged cells—and putting an end to cancer

10

Current age-prolonging therapies are somewhat effective, but coordinated scientific efforts are needed to create lasting treatments for aging

11

Summary of the key insights

12

Selected critiques in brief

13

Final word

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Who should read Ending Aging book

  • Biologists and gerontologists
  • anyone interested in slowing down aging
  • medical professionals working with the aged

About the author of Ending Aging

Aubrey de Grey

Aubrey de Grey

Aubrey de Grey, Ph.D. is biomedical gerontologist and the editor-in-chief of the medical journal Rejuvenation Research. He is the chief science officer at the SENS Research Foundation and an adjunct professor at the Moscow Institute of Physics and Technology. Michael Rae is de Grey’s research assistant at the SENS Foundation.

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